2020

Amatullah H and Jeffrey KL. Epigenome-metabolome-microbiome axis in health and IBD. Current Opinion in Microbiology 2020. Volume 56, Pages 97-108. PMID: 32920333 https://pubmed.ncbi.nlm.nih.gov/32920333/

Adiliaghdam F and Jeffrey KL. Illuminating the human virome in health and disease. Genome Medicine 2020. Jul 27;12(1):66. doi: 10.1186/s13073-020-00766-x. PMID: 32718358 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7384212/

Fraschilla I, Jeffrey KL. The Speckled Protein (SP) Family: Immunity’s Chromatin Readers. Trends Immunol. 2020;41(7):572-585. doi:10.1016/j.it.2020.04.007. PMID: 32386862

Adiliaghdam F, Basavappa M,  Saunders TL, Harjanto D, Prior JT, Cronkite DA, Papavasiliou N, Jeffrey KL. A requirement for Argonaute 4 in mammalian antiviral defense. Cell Reports 2020 Feb 11, Volume 30, Issue 6 p1690-1701. DOI:https://doi.org/10.1016/j.celrep.2020.01.021

2019

Frodermann V, Rohde D, Courties G, Severe N, Schloss MJ, Amatullah H, McAlpine CS, Cremer S, Hoyer FF, Ji F, van Koeverden ID, Herisson F, Honold L, Masson GS, Zhang S, Grune J, Iwamoto Y, Schmidt SP, Wojtkiewicz GR, Lee IH, Gustafsson K, Pasterkamp G, de Jager S, Sadreyev R, MacFadyen J, Libby P, Ridker P, Scadden DT, Naxerova K, Jeffrey KL, Swirski FK, Nahrendorf M, Exercise reduces inflammatory cell production and cardiovascular inflammation via instruction of hematopoietic progenitor cells. Nature Medicine. Nov 7 doi: 10.1038/s41591-019-0633-x. PMID: 31700184

Mani, V, Bromley SK, Äijö T, Mora-Buch R, Carrizosa E, Warner RD, Hamze M, Sen DR, Chasse AY, Lorant A, Griffith JW, Rahimi RA, McEntee CP, Jeffrey KL, Marangoni F, Travis MA, Lacy-Hulbert A, Luster AD, Mempel TR. Conditioning of naïve CD8+ T cells for tissue-resident memory formation. Science Oct 11;366(6462). PMID: 31601741

2017

Murano T, Najibi M, Paulus GLC, Adiliaghdam F, Valencia-Guerrero A, Selig M, Wang X, Jeffrey K, Xavier RH, Lassen KG, Irazoqui JE. Transcription factor TFEB cell-autonomously modulates susceptibility to intestinal epithelial cell injury in vivo. Scientific Reports 2017 Oct 24;7(1):13938. doi: 10.1038/s41598-017-14370-4. PMID: 29066772

Mehta S, Cronkite DA, Basavappa M, Saunders TL, Adiliaghdam F, Amatullah H, Morrison SA, Pagan JD, Anthony RM, Tonnerre P, Lauer GM, Lee JC, Digumarthi S, Pantano L, Sui SJH, Ji F, Sadreyev R, Zhou C, Mullen AC, Kumar V, Li Y, Wijmenga C, Xavier RJ, Means TK, Jeffrey KL. Maintenance of macrophage transcriptional programs and intestinal homeostasis by epigenetic reader SP140. Science Immunology 2017;2(9). DOI: 10.1126/sciimmunol.aag3160. PMID: 28783698

Jeffrey KL, Li Y, Ding SW. Reply to ‘Questioning antiviral RNAi in mammals’. Nature Microbiology 2017 Apr 25;2:17053. doi: 10.1038/nmicrobiol.2017.53. PMID: 28440274

Fusco DN, Pratt H, Kandilas S, Cheon SS, Lin W, Cronkite DA, Basavappa M, Jeffrey KL, Anselmo A, Sadreyev R, Yapp C, Shi X, O’Sullivan JF, Gerszten RE, Tomaru T, Yoshino S, Satoh T, Chung RT. HELZ2 Is an IFN Effector Mediating Suppression of Dengue Virus. Front Microbiol. 2017 Feb 20;8:240. doi: 10.3389/fmicb.2017.00240. PMID: 28265266

2016

Li Y, Basavappa M, Lu J, Dong S, Cronkite DA, Prior JT, Reinecker HC, Hertzog P, Han Y, Li WX, Cheloufi S, Karginov FV, Ding SW, Jeffrey KL. Induction and suppression of antiviral RNA interference by influenza A virus in mammalian cells. Nature Microbiology 2016;2:16250. PMID: 27918527.

Bandyopadhaya A, Tsurumi A, Maura D, Jeffrey KL, Rahme LG. A quorum-sensing signal promotes host tolerance training through HDAC1-mediated epigenetic reprogramming. Nature Microbiology. 2016 Oct 3;1:16174. doi: 10.1038/nmicrobiol.2016.174. PMID: 27694949

2015

Mehta S, Jeffrey KL. Beyond receptors and signaling: epigenetic factors in the regulation of innate immunity. Immunol Cell Biol. 2015;93(3):233-44. PMID: 25559622.

2014

Chiang HS, Zhao Y, Song JH, Liu S, Wang N, Terhorst C, Sharpe AH, Basavappa M, Jeffrey KL, Reinecker HC. GEF-H1 controls microtubule-dependent sensing of nucleic acids for antiviral host defenses. Nature Immunology2014;15(1):63-71. PMID: 24270516.

2012

Marazzi I, Ho JS, Kim J, Manicassamy B, Dewell S, Albrecht RA, Seibert CW, Schaefer U, Jeffrey KL, Prinjha RK, Lee K, Garcia-Sastre A, Roeder RG, Tarakhovsky A. Suppression of the antiviral response by an influenza histone mimic. Nature. 2012;483(7390):428-33. PMID: 22419161.

2010

Nicodeme E*, Jeffrey KL*, Schaefer U, Beinke S, Dewell S, Chung CW, Chandwani R, Marazzi I, Wilson P, Coste H, White J, Kirilovsky J, Rice CM, Lora JM, Prinjha RK, Lee K, Tarakhovsky A. Suppression of inflammation by a synthetic histone mimic. Nature. 2010;468(7327):1119-23. PMID: 21068722. *Contributed equally. f1000.com/7111956

Cheong C, Matos I, Choi JH, Dandamudi DB, Shrestha E, Longhi MP, Jeffrey KL, Anthony RM, Kluger C, Nchinda G, Koh H, Rodriguez A, Idoyaga J, Pack M, Velinzon K, Park CG, Steinman RM. Microbial stimulation fully differentiates monocytes to DC-SIGN/CD209(+) dendritic cells for immune T cell areas. Cell. 2010;143(3):416-29. PMID: 21029863f1000.com/6245956

Yang JS, Maurin T, Robine N, Rasmussen KD, Jeffrey KL, Chandwani R, Papapetrou EP, Sadelain M, O’Carroll D, Lai EC. Conserved vertebrate mir-451 provides a platform for Dicer-independent, Ago2-mediated microRNA biogenesis. Proc Natl Acad Sci U S A. 2010;107(34):15163-8. PMID: 20699384.

2007

Jeffrey KL, Camps M, Rommel C, Mackay CR. Targeting dual-specificity phosphatases: manipulating MAP kinase signalling and immune responses. Nature Reviews Drug Discovery. 2007;6(5):391-403. PMID: 17473844.

Jeffrey K. Rechallenging immunological memory. Nature Medicine. 2007;13(10):1142. PMID: 17917658.

2006

Jeffrey KL, Brummer T, Rolph MS, Liu SM, Callejas NA, Grumont RJ, Gillieron C, Mackay F, Grey S, Camps M, Rommel C, Gerondakis SD, Mackay CR. Positive regulation of immune cell function and inflammatory responses by phosphatase PAC-1. Nature Immunology. 2006;7(3):274-83. PMID: 16474395f1000.com/1031133

2002

Moffatt JD, Jeffrey KL, Cocks TM. Protease-activated receptor-2 activating peptide SLIGRL inhibits bacterial lipopolysaccharide-induced recruitment of polymorphonuclear leukocytes into the airways of mice. Am J Respir Cell Mol Biol. 2002;26(6):680-4. PMID: 12034566.

Technology.org

Technology.org wrote a piece on our SP140 paper in Science...

2020

Fraschilla I, Jeffrey KL. The Speckled Protein (SP) Family: Immunity’s Chromatin Readers. Trends Immunol. 2020;41(7):572-585. doi:10.1016/j.it.2020.04.007. PMID: 32386862

Adiliaghdam F, Basavappa M,  Saunders TL, Harjanto D, Prior JT, Cronkite DA, Papavasiliou N, Jeffrey KL. A requirement for Argonaute 4 in mammalian antiviral defense. Cell Reports 2020 Feb 11, Volume 30, Issue 6 p1690-1701. DOI:https://doi.org/10.1016/j.celrep.2020.01.021

2019

Frodermann V, Rohde D, Courties G, Severe N, Schloss MJ, Amatullah H, McAlpine CS, Cremer S, Hoyer FF, Ji F, van Koeverden ID, Herisson F, Honold L, Masson GS, Zhang S, Grune J, Iwamoto Y, Schmidt SP, Wojtkiewicz GR, Lee IH, Gustafsson K, Pasterkamp G, de Jager S, Sadreyev R, MacFadyen J, Libby P, Ridker P, Scadden DT, Naxerova K, Jeffrey KL, Swirski FK, Nahrendorf M, Exercise reduces inflammatory cell production and cardiovascular inflammation via instruction of hematopoietic progenitor cells. Nature Medicine. Nov 7 doi: 10.1038/s41591-019-0633-x. PMID: 31700184

Mani, V, Bromley SK, Äijö T, Mora-Buch R, Carrizosa E, Warner RD, Hamze M, Sen DR, Chasse AY, Lorant A, Griffith JW, Rahimi RA, McEntee CP, Jeffrey KL, Marangoni F, Travis MA, Lacy-Hulbert A, Luster AD, Mempel TR. Conditioning of naïve CD8+ T cells for tissue-resident memory formation. Science Oct 11;366(6462). PMID: 31601741

2017

Murano T, Najibi M, Paulus GLC, Adiliaghdam F, Valencia-Guerrero A, Selig M, Wang X, Jeffrey K, Xavier RH, Lassen KG, Irazoqui JE. Transcription factor TFEB cell-autonomously modulates susceptibility to intestinal epithelial cell injury in vivo. Scientific Reports 2017 Oct 24;7(1):13938. doi: 10.1038/s41598-017-14370-4. PMID: 29066772

Mehta S, Cronkite DA, Basavappa M, Saunders TL, Adiliaghdam F, Amatullah H, Morrison SA, Pagan JD, Anthony RM, Tonnerre P, Lauer GM, Lee JC, Digumarthi S, Pantano L, Sui SJH, Ji F, Sadreyev R, Zhou C, Mullen AC, Kumar V, Li Y, Wijmenga C, Xavier RJ, Means TK, Jeffrey KL. Maintenance of macrophage transcriptional programs and intestinal homeostasis by epigenetic reader SP140. Science Immunology 2017;2(9). DOI: 10.1126/sciimmunol.aag3160. PMID: 28783698

Jeffrey KL, Li Y, Ding SW. Reply to ‘Questioning antiviral RNAi in mammals’. Nature Microbiology 2017 Apr 25;2:17053. doi: 10.1038/nmicrobiol.2017.53. PMID: 28440274

Fusco DN, Pratt H, Kandilas S, Cheon SS, Lin W, Cronkite DA, Basavappa M, Jeffrey KL, Anselmo A, Sadreyev R, Yapp C, Shi X, O’Sullivan JF, Gerszten RE, Tomaru T, Yoshino S, Satoh T, Chung RT. HELZ2 Is an IFN Effector Mediating Suppression of Dengue Virus. Front Microbiol. 2017 Feb 20;8:240. doi: 10.3389/fmicb.2017.00240. PMID: 28265266

2016

Li Y, Basavappa M, Lu J, Dong S, Cronkite DA, Prior JT, Reinecker HC, Hertzog P, Han Y, Li WX, Cheloufi S, Karginov FV, Ding SW, Jeffrey KL. Induction and suppression of antiviral RNA interference by influenza A virus in mammalian cells. Nature Microbiology 2016;2:16250. PMID: 27918527.

Bandyopadhaya A, Tsurumi A, Maura D, Jeffrey KL, Rahme LG. A quorum-sensing signal promotes host tolerance training through HDAC1-mediated epigenetic reprogramming. Nature Microbiology. 2016 Oct 3;1:16174. doi: 10.1038/nmicrobiol.2016.174. PMID: 27694949

2015

Mehta S, Jeffrey KL. Beyond receptors and signaling: epigenetic factors in the regulation of innate immunity. Immunol Cell Biol. 2015;93(3):233-44. PMID: 25559622.

2014

Chiang HS, Zhao Y, Song JH, Liu S, Wang N, Terhorst C, Sharpe AH, Basavappa M, Jeffrey KL, Reinecker HC. GEF-H1 controls microtubule-dependent sensing of nucleic acids for antiviral host defenses. Nature Immunology2014;15(1):63-71. PMID: 24270516.

2012

Marazzi I, Ho JS, Kim J, Manicassamy B, Dewell S, Albrecht RA, Seibert CW, Schaefer U, Jeffrey KL, Prinjha RK, Lee K, Garcia-Sastre A, Roeder RG, Tarakhovsky A. Suppression of the antiviral response by an influenza histone mimic. Nature. 2012;483(7390):428-33. PMID: 22419161.

2010

Nicodeme E*, Jeffrey KL*, Schaefer U, Beinke S, Dewell S, Chung CW, Chandwani R, Marazzi I, Wilson P, Coste H, White J, Kirilovsky J, Rice CM, Lora JM, Prinjha RK, Lee K, Tarakhovsky A. Suppression of inflammation by a synthetic histone mimic. Nature. 2010;468(7327):1119-23. PMID: 21068722. *Contributed equally. f1000.com/7111956

Cheong C, Matos I, Choi JH, Dandamudi DB, Shrestha E, Longhi MP, Jeffrey KL, Anthony RM, Kluger C, Nchinda G, Koh H, Rodriguez A, Idoyaga J, Pack M, Velinzon K, Park CG, Steinman RM. Microbial stimulation fully differentiates monocytes to DC-SIGN/CD209(+) dendritic cells for immune T cell areas. Cell. 2010;143(3):416-29. PMID: 21029863f1000.com/6245956

Yang JS, Maurin T, Robine N, Rasmussen KD, Jeffrey KL, Chandwani R, Papapetrou EP, Sadelain M, O’Carroll D, Lai EC. Conserved vertebrate mir-451 provides a platform for Dicer-independent, Ago2-mediated microRNA biogenesis. Proc Natl Acad Sci U S A. 2010;107(34):15163-8. PMID: 20699384.

2007

Jeffrey KL, Camps M, Rommel C, Mackay CR. Targeting dual-specificity phosphatases: manipulating MAP kinase signalling and immune responses. Nature Reviews Drug Discovery. 2007;6(5):391-403. PMID: 17473844.

Jeffrey K. Rechallenging immunological memory. Nature Medicine. 2007;13(10):1142. PMID: 17917658.

2006

Jeffrey KL, Brummer T, Rolph MS, Liu SM, Callejas NA, Grumont RJ, Gillieron C, Mackay F, Grey S, Camps M, Rommel C, Gerondakis SD, Mackay CR. Positive regulation of immune cell function and inflammatory responses by phosphatase PAC-1. Nature Immunology. 2006;7(3):274-83. PMID: 16474395f1000.com/1031133

2002

Moffatt JD, Jeffrey KL, Cocks TM. Protease-activated receptor-2 activating peptide SLIGRL inhibits bacterial lipopolysaccharide-induced recruitment of polymorphonuclear leukocytes into the airways of mice. Am J Respir Cell Mol Biol. 2002;26(6):680-4. PMID: 12034566.